Reply To: Activated Charcoal

  • Haley

    Member
    January 4, 2024 at 11:40 am

    “In 1846, Garrod the elder of Aldersgate Medical School in England, conducted
    the first controlled trial investigating charcoal’s efficacy with several poisons on
    a variety of animals including: dogs, cats, guinea pigs, rabbits and frogs. His
    poison of choice was strychnine, but other studies also included opium, aconite,
    hemlock, belladonna, stramonium, silver nitrate, and mercury. Garrod employed
    an animal charcoal preparation called “ivory black” from which minerals were
    Famous [and Not So Famous] Events in Toxicologic History
    Timothy Erickson, MD, FACEP, FACMT
    extracted by treatment with acid. He was also the first to advocate early postingestion charcoal administration, as well as defining a proper charcoal: poison
    ratio. Similar observations were made in England by Graham and Hoffmann who
    added lethal quantities of strychnine to pale ale which was treated with charcoal.
    After the charcoal was filtered off, the pale ale was found to be palatable, and the
    strychnine was recovered quantitatively from the charcoal.
    On our side of the Atlantic, American physician Hort successfully treated a
    mercury bichloride poisoned patient with a powdered charcoal in 1834. Initial
    charcoal administration was administered 44 hours after ingestion, “which afforded great relief”. In 1848, physician B. Howard Rand of Philadelphia followed
    up Gerrod’s studies and was the first to study charcoal’s efficacy in humans
    — including himself.
    At the beginning of the 20th century, Russian toxicologist Ostrejko demonstrated that super heating charcoal with steam increased its adsorptive power.
    Despite these pioneering studies, charcoal was not used again clinically until
    1960 when re-popularized by pediatricians Holt and Holz: “In our opinion charcoal should be restored to the pharmacopoeia, not as a remedy for flatulence or
    intestinal intoxication, but as an emergency antidote for poisons. A bottle on
    every medicine shelf would go a long way to combat serious poisonings in the
    home.”