Reply To: Johne’s (paratuberculosis)

  • Haley

    December 29, 2023 at 7:00 am

    Understanding the human health implications of Johne’s disease (JD) will depend on resolution of a central question: Is the etiologic agent of Johne’s Disease, Mycobacterium avium subsp. paratuberculosis (Map), a significant cause of disease in humans? More specifically, is Map a cause or the cause of Crohn’s disease (CD), or is it an incidental bystander without clinical significance? This has been a controversial subject attracting strong adherents to both positions, but its resolution is essential for the development of rational approaches to disease management and prevention. Programs designed to limit human exposure to organisms from zoologic and other environmental sources will present enormous challenges if Map is found to be a significant human pathogen. However, the stated task of this committee is not to determine the etiology of CD, or even to determine the link between Johne’s and Crohn’s disease, but to review and make recommendations regarding the control and diagnosis of JD, which, of course, may include human health implications. The question of the JD/CD link was therefore examined in the context of the primary study focus. In addition, because there are two recent and thorough investigations of the relevant evidence by the National Institutes of Health (National Institute of Allergy and Infectious Diseases [NIAID], 1998) and the European Union (European Commission, 2000), these data are dealt with in more general terms.”