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Reply To: Mastitis In Sheep and Goats
- OrganizerSeptember 9, 2023 at 6:56 am
Integration of Network Pharmacology and Molecular Docking to Analyse the Mechanism of Action of Oregano Essential Oil in the Treatment of Bovine Mastitis
Oregano essential oil is a plant essential oil extracted from the plant oregano (Origanum vulgare), which has an antibacterial, anti-inflammatory, and antioxidant effect. Bovine mastitis is a process in which bacterial infection and inflammation co-exist. In this study, network pharmacology technology was used to explore the mechanism of oregano essential oil in the treatment of bovine mastitis, and to predict the core genes and key signaling pathways exerting therapeutic effects. The results showed that the key action targets of oregano essential oil in the treatment of dairy bovine mastitis were TNF, TLR4, ALB, IL-1β, TLR2, IL-6, IFNG, and MyD88, and the main signaling pathways were PI3K-Akt, MAPK, IL-17, NF-κ B. The molecular docking confirmed that thymol and carvacrol in oregano essential oil had a good binding ability to the core targets of TNF, IL-6, MyD88, and ALB. These results indicated that thymol and carvacrol had good anti-inflammatory effects. Therefore, oregano essential oil was considered to have a good therapeutic effect on bovine mastitis.