Reply To: Copper

  • theholisticgoat

    August 28, 2023 at 2:20 pm

    Copper Supplementation, A Challenge in Cattle


    Ensuring adequate copper supplementation in ruminants is a challenging task due to the complexity of copper metabolism in these animals. The three-way interaction between copper, molybdenum and sulphur (Cu-Mo-S) in the rumen makes ruminants, particularly cattle, very susceptible to suffering from secondary copper deficiency. Paradoxically, excessive copper storage in the liver to prevent deficiency becomes a hazard when ruminants are fed copper-supplemented diets even slightly above requirements. While cattle were traditionally thought to be relatively tolerant of copper accumulation, and reports of copper poisoning were until recently somewhat rare, in recent years an increased number of episodes/outbreaks of copper toxicity in cattle, particularly in dairy cattle, have been reported worldwide. The growing number of lethal cases reported seems to indicate that copper intoxication is spreading silently in dairy herds, urging the development of strategies to monitor herd copper status and improve farmers’ awareness of copper toxicity. In fact, monitoring studies carried out on numerous samples collected from culled animals in slaughterhouses and/or diagnostic laboratories have demonstrated that large numbers of animals have hepatic copper concentrations well above adequate levels in many different countries. These trends are undoubtedly due to copper supplementation aimed at preventing copper deficiency, as dietary copper intake from pasture alone is unlikely to cause such high levels of accumulation in liver tissue. The reasons behind the copper overfeeding in cattle are related both to a poor understanding of copper metabolism and the theory of “if adding a little produces a response, then adding a lot will produce a better response”. Contrary to most trace elements, copper in ruminants has narrow margins of safety, which must also be formulated considering the concentrations of copper antagonists in the diet. This review paper aims to provide nutritionists/veterinary practitioners with the key points about copper metabolism in cattle to guarantee an adequate copper supply while preventing excessive hepatic copper loading, which requires à la carte copper supplementation for each herd.

    Some key points I’m adding from the paper:

    “For example, when sulphur and molybdenum are present at quite high levels in the diet, the copper requirement in sheep is 10 mg Cu/kg of diet. However, if molybdenum concentrations in the diet are low, dietary supplementation at 10 mg Cu/kg can lead to toxicity in some breeds [5].”

    Inorganic and organic sulphur compounds are metabolized by microbes in the rumen, thus producing sulphide. Furthermore, sulphur and molybdenum react to form thiomolybdates (mono-, di-, tri- and tetrathiomolybdates). These compounds bind strongly to copper (tri- and tetrathiomolybdates bind copper irreversibly) to form copper thiomolybdates. The bound copper is insoluble, and is therefore not absorbed in the intestine. If there is no copper available in the rumen, the thiomolybdates will either be quickly absorbed through the rumen wall or will be absorbed more slowly via the small intestine and after that pass to bloodstream and can bind to copper in biological compounds.”